PIPELINE. . UCB identified novel modulators of SV2A that show pro-cognitive properties in preclinical models. and we will provide you with regular updates. Under the terms of the agreement, AbbVie will pay Syndesi shareholders a $130 million upfront payment with the potential for Syndesi shareholders to receive additional contingent payments of up to $870 million based on the achievement of certain predetermined milestones. We make long term investments in early stage companies in the US and Europe. When it comes to contacting clinicians and patients, the hospital switchboard can be just as [], AbbVie, alzheimer's disease, Clinical Trials, deals, life sciences M&A, neuroscience, North Chicago, UCB. Connecting Health Systems and Life Science Researchers To Maximize the Potential of Real-world Evidence. var prefix = 'ma' + 'il' + 'to'; Company Presentation . VIVES II is funded by a dozen leading Belgian and European investors such as the EUROPEAN INVESTMENT FUND (EIF), SFPI-FPIM, BNP PARIBAS FORTIS PRIVATE EQUITY BELGIUM, BPI FRANCE (France), ING BELGIUM, SOFINA, AXA BELGIUM, BELFIUS, IRD (France), NIVELINVEST, REGION BRUXELLES CAPITAL and by SOPARTEC. read more 14 Dec AbbVies Syndesi acquisition gives the pharma company an additional shot at neurodegeneration. Ferrous(II) glycine sulphate complex (Ferro Sanol), Plain language summaries of study results, Access to Patient-Level Clinical Study Data, Plain Language Summaries of research results, Registration and Results Reporting on Public Registries, Cimzia - Axial spondyloarthritis (axSpA), Privacy Policy for Healthcare Professionals, Syndesi Therapeutics to leverage UCBs expertise in neurology drug discovery to develop potential therapeutics in cognitive disorders with a first-in-class mechanism, Series A financing of 17 M from a syndicate of Belgian and international investors. Though the deal, AbbVie will gain access to Syndesis portfolio of SV2A modulators. The mechanism is currently being evaluated for the potential treatment of cognitive impairment and other symptoms associated with a range of neuropsychiatric and neurodegenerative disorders, such as Alzheimer's disease and major depressive disorder. document.getElementById('cloak45869').innerHTML = ''; X. AbbVie adds to neuroscience pipeline with $1bn Syndesi buy. On March 1, 2022 AbbVie (NYSE: ABBV) reported it has completed the acquisition of Syndesi Therapeutics SA, which will help to expand AbbVie's neuroscience portfolio (Press release, AbbVie, MAR 1, 2022, View Source [SID1234609248]). Type Founded in December 2017 and based in Belgium, Syndesi is a clinical stage biotechnology company pioneering the development of novel therapeutics that modulate synaptic function to relieve the symptoms of cognitive impairment. Novo Holdings and Fountain Healthcare Partners are the most recent investors. Regulating synaptic transmission represents a promising approach to treating Alzheimer's Disease and other disorders with cognitive impairment. Milestone payments could bring shareholders of the biotech up to $870 million more. var addy45869 = 'info' + '@'; Driven by science. Pipeline Prospector delivers free access to a database of Neurology drugs under clinical trials which made headlines done by Syndesi Therapeutics The total value of the deal could. IMPROVING THE LIVES OF PATIENTS AND THEIR FAMILIES. Products or potential products which are the subject of partnerships, joint ventures or licensing collaborations may be subject to differences between the partners. Syndesi Therapeutics is developing molecules that uniquely modulate the synaptic vesicle protein SV2A, which plays a central role in synaptic transmission (the communication between neurons in the brain). +972 77 555 8482 +31 35 808 0509 Bone Therapeutics has a broad portfolio of innovative allogeneic cell therapy solutions across a range of indications. Send. //-->. Syndesi Therapeutics is a clinical stage biotechnology company pioneering the development of novel therapeutics that modulate synaptic function to relieve the symptoms of cognitive impairment seen in multiple CNS disorders, including Alzheimers Disease, schizophrenia and depresson. You are at any time able to change your cookie preferences via the cookie settings on the website. Syndesi will build on a rich legacy of work by UCB to further develop these novel SV2A modulators to investigate their potential to improve cognition in diseases such as Alzheimers Disease, other dementias and cognitive impairment associated with schizophrenia. www.jjdc.com. Novo Holdings A/S (formerly Novo A/S) is the Novo Nordisk Foundation's wholly owned holding company for Novo Nordisk A/S and Novozymes A/S.Novo Holdings A/S was established in 1999 and manages the Novo Nordisk Foundation's assets, which in 2021 was worth almost DKK 700 billion Danish Kroner (approximately US$93.73 billion) and is the largest charitable foundation in the world making Novo . Revolutionary intracellular screening platform creates new opportunities to discover first-in-class therapeutics to address challenging disease targets. Their latest funding was raised on Sep 28, 2020 from a Series A round. Within the life science sector, specific areas of interest to Fountain include specialty pharma, medical devices, biotechnology and diagnostics. "There is a major unmet need for new therapies that can help improve cognitive function in patients suffering from difficult-to-treat neurologic diseases," saidTom Hudson, M.D., senior vice president, R&D, chief scientific officer, AbbVie. Other executives include John Kemp, Chief Scientific Officer; Torsten Madsen, Chief Medical Officer and 4 others. In addition to being the major shareholder in the Novo Group companies, Novo Holdings provides seed and venture capital to development-stage companies, takes significant ownership positions in well-established companies within the life sciences and manages a broad portfolio of financial assets. according to fleur jeffries of pm live, "the acquisition further reinforces abbvie's neurology pipeline, as four years ago, syndesi therapeutics gained the rights to ucb's synaptic vesicle protein 2a (sv2a) programme, which aims to achieve synaptic efficiency, targeting the communication between neurons in the brain, which - most notably in The UK Life Sciences team advised Syndesi Therapeutics and its shareholders on Syndesi's acquisition by AbbVie (NYSE: ABBV). The Company's approach is aimed at treating Alzheimer's Disease and other disorders with cognitive impairment. All rights reserved. All statements, other than statements of historical fact, are statements that could be deemed forward-looking statements, including estimates of revenues, operating margins, capital expenditures, cash, other financial information, expected legal, political, regulatory or clinical results and other such estimates and results. UCB - Inspired by patients. Read More Our Science More from news Approximately 1 fully matching, plus 0 partially . North Chicago, Illinois-based AbbVie announced Tuesday that it paid $130 million up front to acquire Syndesi Therapeutics. There is no guarantee that new product candidates in the pipeline will progress to product approval or that new indications for existing products will be developed and approved. Under the deal, AbbVie also gained access to TeneoOne drug, TNB-383B, indicated to treat relapsed or refractory multiple myeloma. The pharmaceutical industry's most comprehensive news and information delivered every month. About Syndesi Therapeutics . Syndesi Therapeutics has raised a total of 26.2M in funding over 3 rounds. Our Pipeline Job Postings. Syndesi's unique molecules act pre-synaptically to enhance synaptic efficiency by positively modulating the function of synaptic vesicle protein 2A (SV2A), which plays a central role in regulating neurotransmission. Syndesi, which is based in Belgium, aims to treat brain disorders by reducing the symptoms of cognitive impairment. MT . 2007 -2022 UCB S.A., Belgium. The company has also benefited from support from the Walloon Region. . Important factors that could result in such differences include: changes in general economic, business and competitive conditions, the inability to obtain necessary regulatory approvals or to obtain them on acceptable terms, costs associated with research and development, changes in the prospects for products in the pipeline or under development by UCB, effects of future judicial decisions or governmental investigations, product liability claims, challenges to patent protection for products or product candidates, changes in laws or regulations, exchange rate fluctuations, changes or uncertainties in tax laws or the administration of such laws and hiring and retention of its employees. MT-2000 is a class of agents that are designed to precisely convert pro-inflammatory M1 Macrophages to anti-inflammatory M2 macrophages. Clinical studies at UCB: How are medicines made and tested? In the life science sector, SRIW is investor in more than 30 companies such as I.B.A., Celyad, or Ogeda of which it recently exited. It has been a pleasure to partner with our investors to investigate the potential of SDI-118 in early clinical studies. Macrophage Therapeutics has developed a proprietary targeted steroid (MT-2000 class) designed to specifically treat the disease-causing cells quarterbacking the body's inflammatory response (Macrophages). A new whitepaper from Ventech Solutions offers helpful guidance for how to mitigate the hidden risks low-code platforms present. Regulating the synaptic transmission is a promising approach to treat Alzheimer's disease and other disorders with cognitive impairment. For more information about AbbVie, please visit us atwww.abbvie.com. 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Syndesi Therapeutics is a clinical stage biotechnology company pioneering the development of novel therapeutics that modulate synaptic function to relieve the symptoms of cognitive impairment. Read more Press releases Also, UCB or others could discover safety, side effects or manufacturing problems with its products after they are marketed. Syndesi has an exclusive, worldwide license from UCB to develop and commercialise a series of novel, pro-cognitive SV2A modulators. This acquisition gives AbbVie access to Syndesi's portfolio of novel modulators of the synaptic vesicle protein 2A (SV2A), including its lead molecule SDI-118. Gain Therapeutics is redefining drug discovery with its SEE-Tx target identification platform. Prilenia Therapeutics. Do not sell my information, Bain Capital-Backed Emalex Bio Lands $250M for Pivotal Test of Tourette Drug, How To Create Digital Health Apps That Serve as Useful Tools (Not Unnecessary Work), Why Digital Health Collaborations Are the Future of Medtech, Rubiuss New Cell Therapy Strategy Runs Out of Time & Money; Workforce Is Cut by 82%, Startup Founded by Brown Undergrads Raises $14M to Improve Care for Vulnerable Seniors, AMA: CMS 2023 Physician Fee Schedule Would Create Financial Instability, Carta Healthcare Rakes in $20M with Hopes of Selling its Tech to More Hospitals, CVS, Walgreens Will Pay $10 Billion Total To Settle Opioid-Related Lawsuits. The mechanism is now being studied to potentially treat cognitive impairment and other symptoms linked to various neurodegenerative and neuropsychiatric diseases such as major depressive disorder and Alzheimers disease. Tick the boxes of the newsletters you would like to receive. - Expands AbbVie's neuroscience portfolio, adding first-in-class modulators of the synaptic vesicle protein 2A, including lead molecule SDI-118 currently in Phase 1b studies, - Novel mechanism will be evaluated for the potential to mitigate synaptic dysfunction associated with cognitive deficits across a range of neuropsychiatric and neurodegenerative disorders. About UCB Ventures. About Syndesi Therapeutics Founded in December 2017 and based in Belgium, Syndesi is a clinical stage biotechnology company pioneering the development of novel therapeutics that modulate synaptic function to relieve the symptoms of cognitive impairment. Syndesi Therapeutics is building upon a rich legacy of research on SV2A conducted at UCB. This acquisition gives AbbVie access to Syndesi's portfolio of novel modulators of the synaptic vesicle protein 2A (SV2A), including its lead molecule SDI-118. About Syndesi Therapeutics Founded in December 2017 and based in Belgium, Syndesi is a clinical stage biotechnology company pioneering the development of novel therapeutics that modulate synaptic function to relieve the symptoms of cognitive impairment. See the full leadership team at Craft. This email address is being protected from spambots. Get the latest industry news first when you subscribe to our newsletter. They are also entitled to get further contingent payments of up to $870m on meeting specific pre-set milestones. The firm deploys the majority of its capital in Europe, with the balance in the United States. AbbVie has bolstered its neuropsychiatric and neurodegenerative portfolio with the acquisition of Belgium-based Syndesi Therapeutics in a deal valued at up to $1 billion. About Bone Therapeutics . OUR PIPELINE JOIN US TODAY Syndesis molecule is currently in early-stage clinical development as a way to target nerve terminals to enhance synaptic efficiency. info@prilenia.com. flanders.bio wants to improve your user experience on this website. document.getElementById('cloak45869').innerHTML += '' + addy45869+'<\/a>'; Therapeutic botox accounted for $2.45 billion in 2021 sales, making it the companys top neuro product. SIRP-DIRECTED ANTIBODIES IN DEVELOPMENT Our novel monoclonal antibodies are designed to change the lives of patients with immunological diseases and cancer. I am thrilled to be working with the company which is supported by scientists at UCB and able to leverage Janssen neuroscience expertise via a presence at the JLINX incubator, all in an effort to develop products that could one day make a meaningful difference for patients suffering from cognitive impairment.. According to the deal, shareholders of Syndesi will receive an upfront payment of $130m from AbbVie. Thanks for submitting! The fund invests throughout Europe in start-up and early-stage companies with high growth potential focusing on technologies that provide transformational improvements in the biopharmaceutical, pharmaceutical, diagnostics and agricultural sectors. Clinical trial records show the drug is currently in two Phase 1b tests, one enrolling elderly patients with cognitive decline and the other testing the drug candidate in adults in remission from depression. AbbVie R&D senior vice-president and chief scientific officer Tom Hudson said: There is a major unmet need for new therapies that can help improve cognitive function in patients suffering from difficult-to-treat neurologic diseases.
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